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Origin
Sonic KnifeAfter being forcibly spawned from the Venom symbiote by the Life Foundation, the Scream symbiote is then bonded to a woman named Donna. Like the other members of Life Foundation, Donna Diego volunteered to be fused with a symbiote. After continued failed attempts at controlling the symbiote she went to seek guidance from Venom and Scarlet Spider. Being rejected by both she came to the conclusion that all symbiotes were evil and must die. While she managed to kill all her siblings, with a sonic knife, she was stopped by Venom. Later on she protected the remaining symbiotes on earth from Xenophage, as a way to repent for her crimes. Currently she joined up with Sinister Six.
Donna devoted herself to kill all of the other symbiotes cause she thought that they were evil like herself. Venom seemed to be the main target, since she fought him on several occasions. Until recently she regrets her villanous ways and began to help the other symbiotes hosts by teaching them how to deal with there symbiotic half.
Donna eventually teams up with Venom when he was in a fight with Dirt Nap. Then she found herself stuck in Dirt Nap's ship, eventually she stopped him. She decided to follow in Venom's footsteps and stay netural between good and evil.
Death
Long after Eddie Brock and Venom had become separate entities, Eddie went on a symbiote hunting spree. Eddie's first target was her brother Hybrid, whom he killed with what seemed to be incendiary bullets. Eddie knew that Scream would hear about Hybrid's death, and left a trail for her to follow. When Scream arrived at the scene, Eddie used a sonic device to paralyze her, and then revealed that he had a knife set in a furnace. He then used the burning hot knife to stab Scream to death, mirroring Scream's infamous use of a sonic knife.
Creation

Scream was created by David Michelinie, Ron Lim, Sam DeLarosa and Al Milgrom in 1993 and first appeared in Venom: Lethal Protector # 4.
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