PIS aside, how do they hurt Rhino? He is an 85 tonner with great durability. Iron Fist at a maximum punch could hurt him and Cage (25 tonner) could have some effect. But a thunder clap or a ground pound could take Iron Fist out and Cage is going to get hit if he tangles with Rhino and he can't really tank his punches.
Sandman is in the same boat. Unless they trick him into great heat making glass or a flood to wash him away they really can't hurt him and his team members can help save him from such situations. Meanwhile he can crush and suffocate any of them with no special set up required.
Carnage is a beast, stronger, faster, and more agile than any of his opponents. In a team setting, getting him with sonics or fire is more difficult as the other team members can shield or save him from such attacks.
Electro can one shot any of the opponents though he is at least squishy and can be hurt.
Lizard and Hobgoblin are tough physically and can deal out more damage than any of their opponents outside of a haymaker by Cage or Iron First.
In a real fight without the heroes win comic directive, I don't see how they lose.
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