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Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became Spider-Man.
J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
Peter Parker's aunt-by-marriage and one of the most important people in his life.
Editor-in-Chief of the Daily Bugle, and perhaps the best friend to J. Jonah Jameson.
James Sanders was a member of the Squadron Sinister known as Whizzer until he pursued a solo life of crime as Speed Demon. He eventually found himself a member of the Thunderbolts despite being unsure if he even wanted to reform.
Betty Brant started as a personal secretary at the Daily Bugle and later became a top reporter. Betty is also one of the many love interests of Peter Parker and ex-girlfriend of Flash Thompson
Enemy of Spider-Man and sometimes ally of The Kingpin.
Spider-Man villain with Hydrokinesis (the ability to control water), often part of teams with vendettas against the wall-crawler. Embodies the literal opposite of Spidey's other foe, Sandman.
Former pro baseball player who became a known criminal as the Boomerang. After fighting towards some semblance of redemption as a member of the Thunderbolts, he lead the seventh incarnation of the Sinister Six.
Dutch criminal with Cobra like powers, who went on as the third leader of The Serpent Society.
Formerly a brilliant scientist, Jonathon Ohnn gained the ability to create teleportation portals when his research went wrong. Turning to a life of crime and adopting the moniker of 'The Spot', Ohnn has since become a semi-frequent adversary to Spider-Man and is oft treated as a less than serious threat despite his capabilities.
A former member of the Circus of Crime, Griffin is a gamma-irradiated member of the Gamma Corps.
Jackpot is a new registered hero with The Initiative who fights in New York City. There have been two people to take the Jackpot identity, Alana Jobson who died, and first and current heir Sara Ehret.
A man who would later take the name of Martin Li, was given an experimental drug which eventually allowed him control of some type of black electrical energy resembling a photographic negative.
He runs bets on superhero battles at the villains bar, The Bar With No Name.
A villain who uses nanites to alter motor vehicles to his liking. Formerly working for Mr. Negative, he is now a member of the Sinister Six.
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