What do you think? Not based on his capabilities but rather his character traits. I'm sure that I would like it. Wesker's capabilities are more realistic than say Apocalypse's powers. Yet, he would still be a formidable threat with his speed, bio-organic weapons, and all. I thought about this after watching Wesker's MVC3 ending.

No

Mentally, possibly with lots and lots of prep. Physically, there are plenty of X-Men who would out right destroy him.

Added that I only meant to discuss him being an X-Men character based on his character traits, personality, occupation, and so on.