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The Wetform A.I. is based on the theories of Professor Masaru Emoto, who observed that water changes composition depending on emotions one projects upon it. The weapon is also based on Professor Ramsey Norton's infamous creation, Chemo, particularly the plastic shell. S.H.A.D.E. took these two things and created the weapon.
The weapon works by bleeding water that, when drank, infects the drinker. Animals become murderous, and humans either become murderous or lose all intellect. S.H.A.D.E. agent codenamed Pilot Zbigniew X drank the water and tried to communicate with the Wetform A.I. He took it upon himself to spread the water, realizing that water "does not like us telling it what to do". The water infected and seemingly killed a S.H.A.D.E. agent called Replika. As Frankenstein and the Bride are both dead, S.H.A.D.E. sent them in, in hopes that the water would not affect them.
It did not, and the two were able to confront Pilot Z-X and the Wetform. The Bride killed Pilot Z-X by decapitating him, preserving his head. Frankenstein was able to stop the Wetform A.I. by shooting it, puncturing the shell. Salvation Valley, the town that had been infected, was destroyed by nuclear blast, containing the infection.

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