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Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became Spider-Man.
J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
Peter Parker's aunt-by-marriage and one of the most important people in his life.
Former enemy of Spider-Man and the Fantastic Four, Sandman reformed after realising he was unhappy with his life. He joined the Avengers and later Silver Sable's Wild Pack. Sandman eventually returned to crime after being brainwashed by the Wizard, but sometimes still displays desire to better himself.
Gwen Stacy was the first true love of Peter Parker. She's best known for her tragic death by being thrown off from the Brooklyn Bridge by the Green Goblin. The Earth-65 version is Spider-Gwen who is a major player in the Spider family.
Doctor Octopus is a supervillain originating from Marvel Comics. A former nuclear physicist and atomic researcher, Otto Octavius' life changed forever when one of his experiments went horribly wrong involving his four mechanical appendages used to assist him in his experiments. From then on, Octavius soon after his initial encounter has become one of the most dangerous supervillains in the Marvel Universe.
Flash frequently bullied Peter Parker but was actually Spider-Man's greatest fan. In time, Flash befriended Peter, became a decorated war hero, and eventually joined the Marvel superheroes as a symbiote host, first with Venom and then with Anti-Venom.
Swindled by his business partner out of his equal share of the profits from their company, Adrian Toomes set out for revenge by using a flying harness of his own design. He has however, met defeat several times at the hands of his arch-nemesis, The Amazing Spider-Man.
Betty Brant started as a personal secretary at the Daily Bugle and later became a top reporter. Betty is also one of the many love interests of Peter Parker and ex-girlfriend of Flash Thompson
Harry Osborn is the best friend of Peter Parker, the Amazing Spider-Man. His father is Norman Osborn, a global industrialist and billionaire.
Mysterio was a formidable foe to Spider-Man. So much so that his arts of illusion were carried on by others after the original Mysterio's death. The original Mysterio, Quentin Beck, has recently returned. The events behind his resurrection are currently shrouded in mystery.
Dmitri Smerdyakov, AKA Chameleon, was first member of an inexperienced Spider-Man's rogue's gallery. The Chameleon is an elite spy and a master of disguise, using a variety of masks, technology, and other inventive techniques to flawless mimic the appearance and mannerisms of virtually anyone. Although he has been revealed to be the half-brother of Kraven The Hunter, the face behind his trade-mark white mask – worn even beneath his other masks – has never been seen.
Former chief scientist on Traan, a planet in the Microverse. He traveled to Earth to conquer the planet with his psycho ray. He remains a constant foe for the Fantastic Four.
Norrin Radd of Zenn-La is the mighty herald of Galactus, the devourer of worlds. Gifted with the Power Cosmic and a trusty board that's faster than lightspeed, which he can summon at will whenever needed, Norrin Radd travels to distant reaches throughout the universe as the Silver Surfer.
A retired New York Police Department captain and the father of Gwen Stacy.
A former boxer whom is friends with the Amazing Spider-man
Mary Jane Watson is an actress and a major love interest of Peter Parker aka Spider-Man. They have had a long and dramatic on-and-off-again relationship. She's one of the few people who know who he is and still supports him as a close friend and confidante.
Elizabeth Allan was a classmate of Peter Parker. She dated and later married Harry Osborn, Peter's best friend. She has a son named Normie Osborn.
Cletus Kassady is a deranged and highly dangerous serial killer and long-time host to the Carnage symbiote.
A denizen of the Negative Zone who battles Annihilus frequently and became the king of most of the territories of the Negative Zone
Annihilus, a native of the planet Arthos, is the ruler of the Negative Zone and longtime foe of the Fantastic Four. He is a nihilist who is obsessed with finding different ways to extend his lifespan and isn't opposed to destroying all that which he sees as a threat to his existence.
Symkarian ruler and leader of a band of mercenaries known as the Wild Pack. More recently she has allied herself with Misty Knight, Paladin and the Heroes for Hire operation.
Ned Leeds was a Daily Bugle reporter whom Roderick Kingsley brainwashed into becoming the Hobgoblin until his eventual demise.
Former pro baseball player who became a known criminal as the Boomerang. After fighting towards some semblance of redemption as a member of the Thunderbolts, he lead the seventh incarnation of the Sinister Six.
Growing tired of his mechanic job, Abe Jenkins created a suit of armor and became the Beetle. Originally a criminal, he changed his ways as a member of the Thunderbolts, Taking the name MACH-1. Abe became a mainstay of the group and achieved legitimacy as a superhero. As he's upgraded his armor, he's changed his name to reflect the version of his armor, currently MACH-X.
Cassie St. Commons was a typical ESU student until a meeting with Black Marvel changed everything.
Spider-Man villain with Hydrokinesis (the ability to control water), often part of teams with vendettas against the wall-crawler. Embodies the literal opposite of Spidey's other foe, Sandman.
Carnage is the offspring of the alien symbiote Venom. It bonded with the crazed serial killer, Cletus Kasady, thus creating one of Spider-Man's most murderous, brutal, and lethal adversaries.
Editor-in-Chief of the Daily Bugle, and perhaps the best friend to J. Jonah Jameson.
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