Origin

Weapon Plus is a government program introduced to create super-humans to fight in future wars, and eventually evolving to deal with the growing "mutant problem". Originally the only known branch of the Weapon Plus program was the Weapon X program. Weapon X was the code-name for the government group that made Wolverine into a living weapon, infusing his skeleton and claws with the metal Adamantium and honing is mutant skills to make him the ideal killer. At the time Wolverine's code-name was Weapon X.

It was not until much later that Fantomex revealed to the X-Men that Wolverine's program was not simply "Weapon X" (weapon ex), but was Weapon 10 (the roman numeral X). The part of the program that created Wolverine was not the first attempt at perfecting a living weapon, but was instead the tenth installment of the Weapon Plus program.

Generations of Weapon Plus

Weapon 0

Weapon 0 was the basis for Operation: Rebirth.

Weapon I

More commonly known as Operation: Rebirth, Weapon I occurred during WWII. This is the program that created Captain America. The program began with the experiment that turned Steve Rogers into Captain America, but the process was lost immediately after when the scientist involved was killed by a Nazi spy. In an attempt to recreate the formula, the army began testing on African American volunteers, eventually empowering Isaiah Bradley.

Weapon II-III

Animal Testing

Weapon IV-VI

Testing on various ethnic minorities.

Weapon VII

Weapon VII marks the beginning of Weapon Plus tests on mutants.

Weapon VIII-IX

Project: Homegrown. Similar to Weapon I, Weapon Plus tested on human soldiers during the Vietnam War.

Weapon X

The tenth generation of Weapon Plus was responsible for experimentation on Wolverine. Because of his advanced mutant healing factor they were able to graft Adamantium onto his skeleton and claws, making his bones virtually indestructible. Without his healing factor he would not have survived the process. Wolverine was also conditioned and trained to be a killer. Weapon X would split off from the Weapon Plus program, continuing to experiment to create the ultimate weapons out of mutants and retaining their name.

More information on Weapon X can be found on the Weapon X page.

Weapon XI

Unknown.

Weapon XII

Huntsman (aka Zona Cluster 6) was engineered at "The World", another creation of the Weapon Plus program designed as an artificial habitat to train and create super soldiers using Sentinel (nano)technology as well as artificial aging and forced evolution. Zona Cluster 6's mind is composed of millions of viral nanomachines. He infects anything he touches, using host creatures (animals, humans, or mutants) as extensions of his own body.

Weapon XIII

Another creation of "The World", Fantomex (aka Charlie Cluster 7) is another combination of advanced mutant evolution and sentinel nanotechnology.

Weapon XIV

The Stepford Cuckoos were created as clones of Emma Frost, and like their most recent predecessors were developed using nanotechnology. Their telepathic abilities are increased when their minds work as a single unit, and their skeletons house computer technology that can continue to function even after the rest of their bodies have been destroyed. It was originally believed that there were only five of them, but it was later revealed that 1000 were created, together being capable of telepathic feats perhaps unmatched by any single mutant.

Weapon XV

The fifteenth generation of the Weapon Plus program was the Human-Sentinel hybrid Ultimaton.