I've noticed that most of the time when Wasp grows to giant size bad things seem to happen to her. There have been a couple of times when she's grown and nothing serious happens. But the majority of the time she's either been unlucky or accident prone. Here's a list for you.
1. Marvel Feature 6- Wasp grows to giant size for the first time and hits her head on the ceiling and knocks herself out.
2. Avengers 380-382- A giant wasp goes on a rampage through the city causing a lot of destruction.
3. Avengers (Vol 3) 78, 79- Wasp grows to giant size to stop the wreckering crew. But during the battle she accidentally damages a couple of buildings.
4. Avengers (Vol 3) 80, 81- Wasp grows to stop the wrecking Crew from stealin a Quinjet. But her growth destroys part of the Avengers mansion and landing the Quinjet on a small town also partially destroyed,
5. Mighty Avengers 8- Wasp grows to fight against the symbiote infected citizens of New York. But during the battle she gets infected herself turning into a giantCarnage Symbiote.
6. Secret Invasion 7,8- Wasp becomes a bio-bomb and grows to giant size before Thor is forced to teleport her into another dimension before she exploded.