There's been three months since issue #2 and #3 starts with The Killer falling through the sky of another reality's Earth killing superheroes on the way down. He and other members of The Fraternity are on a looting mission to steal a radioactive condom. After the (successful) mission, Wesley goes to the Doll-Master's house where he is told that Fox may have been the one to kill his father. He says he doesn't believe it but it's on his mind when he goes to the Meeting of the Five Families.

The five villains that rule the world meet to discuss things while other villains use the gathering as a way to network. At the meeting, The Professor, Adam One, Ching-Sang, The Future and Mr. Rictus vote on wether or not to go public. It's 3-2 with The Professor, Adam One and Ching-Sang voting against, so Rictus leaves angry. After the meeting The Professor is killed in his limo by Shithead, one of Rictus' henchmen. Mister Rictus wants the world to know that the villains run things and he'll kill anyone who stands in his way.