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Sexton Furnival was a young man who was Death's companion for a day.
A lieutenant-general of the Israel Defense Forces chasing after Yorick Brown in order to ensure the future of her nation.
The girl whom Yorick proposes to (over the phone) just before the plague wipes out the male gender. The majority of the series follows his quest to find her.
Dr. Mann is a geneticist who clones Yorick Brown.
Agent 355 is a member of the secretive Culper Ring and aids Yorick Brown, the last man on Earth, as he tries to find his girlfriend and perhaps save humanity.
Dizzy Cordova's younger brother.
Dizzy Cordova's younger sister.
Since accepting the attache from Agent Graves her life was changed forever. Trained to be a Minuteman, she will be a key player. However as a pawn of Graves her true purpose still remains a mystery.
Timothy Hunter is a young man with the potential to be the greatest mage of his time.
Spider Jerusalem's editor and his oldest friend.
Fred had himself modified with alien DNA and became leader of the Angels 8 transient movement. More than a little self and sex obsessed he also started him own religion.
Spider Jerusalem is an infamous but brilliant gonzo journalist, who once shook The City to it's core. A cynical, foul-mouthed, chain smoking anti-hero, Spider is an absolute crusader for The Truth. He is heavily inspired by gonzo journalism founder Dr. Hunter S. Thompson.
Botanist Alec Holland became the avatar of the Green, known as the Swamp Thing, following his death in a swamp as a result of a horrific accident. With the ability to control any form of plant life, Swamp Thing uses his powers to protect both the human and the plant worlds.
Yorick Brown's pet Capuchin monkey and one of the few male mammals to survive the Plague. He may hold the key to mankind's survival.
The mother of Yorick and Hero Brown.
Seemingly the last man on Earth, amateur escape artist Yorick Brown runs from spies, ninjas, and his own sister as he struggles to find his girlfriend and perhaps save the future of mankind.
One of the seven Endless, inconceivably powerful beings, Death is both lord and personification of all death and life. She is well known for being the opposite of what most people think death is like; rather than being an ominous figure, she is a friend to all under her auspice.
Agent Graves is the shadowy figure that gives people an opportunity to right an injustice in their life by giving them 100 bullets, a gun, and undeniable evidence of the target's wrongdoing
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