Vanessa Fisk was the wife of New York's most powerful crime lord, Wilson Fisk. They had a child, Richard. The Kingpin's family usually took a back seat to whatever Wilson was doing. Richard, embittered by this neglect, made several attempts on his father's empire and his life as both the Schemer and as the original Rose.
In spite of extramarital affairs, most notably with Typhoid Mary, Wilson Fisk's Achilles heel seems to have been his wife. Vanessa's mental health deteriorated as a result of the conflict within her family, and at one point, she disappeared into the underground community belonging to the King, a brutal man who resembled her husband in stature. Daredevil rescued Vanessa and returned her to her husband.
Richard failed again and again to destroy his father's underground empire. However, an attack by Echo left the senior Fisk blinded. A gangster named Sammy Silke convinced Richard, as well as Wilson's most trusted employees, to assassinate the Kingpin. Thought to be dead by many, Wilson was in the care of his personal doctor and a man named Dini. Vanessa learned that her son took part in his assassination and shot him in cold blood after telling him he was a endless disappointment to her.
Wilson Fisk recovered and had Silke killed. Sometime later, he was incarcerated and sentenced to serve time at Ryker's Island Prison. Humiliated, Vanessa disappeared. She reappeared some time later, after arranging for Matt Murdock to escape from Ryker's using the blind hero, Tombstone, and a new version of the Matador, as if it were a game of chess, as she later explained. Confronting Daredevil, Vanessa told Matt he had two choices: he could get Wilson out of jail as the Kingpin's attorney, or she would reveal to the media that he was Daredevil, and will release photos of Daredevil in Europe while Danny Rand was currently impersonating Daredevil back in New York. Murdock choose to not participate in Vanessa's games. She cleared thing up with Matt's Daredevil situation a, knowing he will set Kingpin free. She committed suicide shortly after, and though Wilson Fisk was unable to attend her funeral, he mourned her nonetheless.
Vanessa's gambling boyfriend was killed by Wilson Fisk. They fell in love, got married and shortly after, Richard was born. Eight years later, she was held hostage by Don Rigoletto along with her son because Wilson tried to take over Rigoletto's power base. Richard was killed and Wilson became Kingpin. A grief-stricken Vanessa became an alcoholic, and attempted to kill Wilson Fisk herself, but was stopped by Bullseye. She fled immediately.
Appearances in other media
Vanessa appeared in Spider-Man The Animated Series in two episodes in "Ravages of Time" and "Tablet of Time."