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One of Spider-Man's most dangerous enemies, the electric human dynamo known as Electro has constantly been a major threat for the Amazing Spider-Man.
The amoral industrialist Norman Osborn was transformed by an experimental serum into the maniacal Green Goblin, and has endured over the decades as Spider-Man's most dreaded archenemy. Osborn is known for being the killer of Gwen Stacy, the architect of the Clone Saga, and the one-time director of S.H.I.E.L.D.
After encountering the Kree hero Captain Marvel, Carol Danvers was accidentally subjected to otherworldly radiation that transformed her into a superhuman warrior. Calling herself Ms. Marvel, she established herself as one of the most powerful and prominent heroes and respected member of the Avengers. She has now adopted the mantle of Captain Marvel for herself.
Elizabeth Allan was a classmate of Peter Parker. She dated and later married Harry Osborn, Peter's best friend. She has a son named Normie Osborn.
Mary Jane Watson is an actress and a major love interest of Peter Parker aka Spider-Man. They have had a long and dramatic on-and-off-again relationship. She's one of the few people who know who he is and still supports him as a close friend and confidante.
In the Ultimate Universe, Kenny McFarlane is friends with Peter Parker and Mary Jane Watson. He was also friends with Flash Thompson and developed a crush on the popular transfer student, Kitty Pryde.
The Jackal is an enemy of Spider-Man who played a big role in both of the Clone Sagas. He has since seemingly returned to infest Manhattan with spider-powers for his own sinister ends, organizing test subjects into a spider-powered army.
During the Cold War, Arkady Rossovich was forced into a Soviet version of the Weapon X program in order to become a Russian super soldier. The result of this experiment was the deadly Omega Red.
Shocker is a supervillain originating from Marvel Comics. A self-taught engineer, Herman Schultz created a pair of gauntlets that produces shock waves incorporated into a suit that protects him from the impact of of the blasts. He is a recurring foe of the superhero Spider-Man.
Kitty Pryde (a.k.a. Shadowcat) is a mutant gifted with the ability to become intangible and phase her entire body through solid material. A talented prodigy, she became the poster child of the X-Men; eventually reaching maturation and becoming the team's current leader.
Patsy Walker had long idolized super heroes and after given the chance of a lifetime became 'Hellcat'. She is one of Marvel's oldest characters, dating back to her 'romantic' comic books in the 1940s. She has served on several incarnations of the Defenders and the Avengers.
Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became Spider-Man.
Mr. Sinister is a supervillain originating from Marvel Comics. Nathaniel Essex was a 19th Century scientist that was genetically mutated by Apocalypse, who shared his philosophy of Social Darwinism. Becoming the immortal Mr. Sinister, he is perhaps the greatest geneticist in the world; capable of cloning, creating, enhancing, and controlling mutant abilities. Sinister is one of the X-Men's most dangerous enemies.
Harry Osborn is the best friend of Peter Parker, the Amazing Spider-Man. His father is Norman Osborn, a global industrialist and billionaire.
Susan Storm is a founding member of the Fantastic Four and later the Future Foundation. She is able to create invisible force fields of any shape she conceives and able to turn herself and anything she's in contact with invisible. Sue is the wife of Reed Richards and the mother of their children, Franklin and Valeria.
The second most powerful member of the Fantastic Four and the younger brother of Sue Richards. Due to an accident caused by cosmic radiation in space, he can manipulate fire, turn his entire body into it and fly. While Johnny is known for his impetuous and sometimes reckless nature, he is also a loyal friend and fearless hero.
Peter Parker's aunt-by-marriage and one of the most important people in his life.
Carnage is the offspring of the alien symbiote Venom. It bonded with the crazed serial killer, Cletus Kasady, thus creating one of Spider-Man's most murderous, brutal, and lethal adversaries.
Flash frequently bullied Peter Parker but was actually Spider-Man's greatest fan. In time, Flash befriended Peter, became a decorated war hero, and eventually joined the Marvel superheroes as a symbiote host, first with Venom and then with Anti-Venom.
Doctor Octopus is a supervillain originating from Marvel Comics. A former nuclear physicist and atomic researcher, Otto Octavius' life changed forever when one of his experiments went horribly wrong involving his four mechanical appendages used to assist him in his experiments. From then on, Octavius soon after his initial encounter has become one of the most dangerous supervillains in the Marvel Universe.
Gwen Stacy was the first true love of Peter Parker. She's best known for her tragic death by being thrown off from the Brooklyn Bridge by the Green Goblin. The Earth-65 version is Spider-Gwen who is a major player in the Spider family.
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