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After having just defeated Madelyne Pryor, Jean goes into a state of psychic attack, where she is struggling to deal with Madelyne's memories, as well as Sinster's control of Madelyne. Storm, Cyclops, Psylocke, and Wolverine enter her mind, and they all eventually drive Sinister out of her mind. They then decide to attack Sinister.
They go to Sinister's base, now Xavier's School. While searching, different groups are assaulted by Blockbuster, Sabretooth, and Malice/Polaris. They all are defeated, but at the last second Sinister causes an explosion to defeat them all. Only Longshot stands against Sinister and Malice.