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Stanley Ipkiss buys a mask from an oddities store for his girlfriend. On his way out he is accosted and attacked by a biker gang known as "The Butchers". As Stanley drives home after the attack he fantasises about killing the gang in various ways. The mask starts talking to him telling him to "waste" the biker gang. Stanley puts this off to feeling upset after the attack. He gives the mask to Katherine and go's to bed.
During the night Ipkiss wakes to use the bathroom, when he enters the bathroom he see's the mask on the toilet. Thinking it was a prank to scare him he put's on the mask to give Katherine a taste of his own medicine. This changes him into Big Head and, feeling pretty good, he shimmies down the drainpipe and murders the biker gang that attacked Stanley earlier that day. After a while Stanley starts to become irritable and almost hits Katherine, he manages to stop himself then takes the mask and goes out to kill more people who have wronged him, this time two mechanics at Yorky's Mufflers and his old school teacher.
After killing everyone on his list he decides to become a super hero, however Katherine throws the mask in the trash thinking that Stanley is obsessed. She was right, Ipkiss overreacts to the mask being thrown out but decides it will be fine seeing as he has already killed everyone on his list, he laughs at the deaths of his victims which are on the news and is subsequently thrown out of Katherine's apartment.
Stanley then realises that Katherine must have gotten the mask out of the garbage and climbs in to her apartment through a window, he wakes Katherine whilst doing this and she calls the police. Because the police take too long to arrive she waits for the "Burglar" to come through the door and quite literally lamps him (she smashes a lamp over his head). She realises it was Stanley and when the police arrive she tries to get rid of them but Stanley who had found the mask kills the police and then goes on a rampage murdering police officers. Lt. Kellaway, who has been investigating the Big Head murders, manages to corner Ipkiss on the roof and shoots him (again). Stanley falls off the roof and manages to steal a police car. Meanwhile, Katherine has figured out that Stanley is actually Big Head, when Stanley goes back to his apartment Katherine is waiting for him, when he takes off the mask she shoots him dead and has wears the mask herself.