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Spider-Man and Juggernaut are trapped in an unearthly realm by a being of mind-bending power. But who is their tormentor? What's his connection with Spider-Man? And why does he hate the Juggernaut? All is revealed in a final showdown that threatens to shake Manhattan to its very foundations -- and brings the Spider-Man/Juggernaut Trilogy to a fateful conclusion!

Also, “Half-Man, Half-Reptile…the Lizard will take over all of Earth unless Spider-Man alone can stop him!” With these words, Dr. Curt Connors, the man who would be The Lizard, ushered a new kind of villainy into Spider-Man’s life. Now a widower with a son in foster care, and working at the bottom of the pharmaceutical industry, Connors is a broken, shell of a man…how long will it be before a Lizard breaks that shell?! How will it affect Peter Parker’s date with Carlie Cooper?! How is the Black Cat involved?

Plus, in the aftermath of Siege, an Osborn falls! Where does Norman Osborn’s fall leave his son, Harry? In the wake of the Siege of Asgard and the dawn of a new Age of Heroes, the world finally knows what his father is – but what is Harry himself? And who has taken on the American Son armour? And what does Gabriel Stacey have to do with it?!

Includes material reprinted from Amazing Spider-Man #629-630 and Amazing Spider-Man: American Son #1!

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