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A university professor that taught physics and Peter Parker was one of his student teachers.
A man who would later take the name of Martin Li, was given an experimental drug which eventually allowed him control of some type of black electrical energy resembling a photographic negative.
Junkie who hangs out at the homeless shelter where May Parker volunteers.
Jackpot is a new registered hero with The Initiative who fights in New York City. There have been two people to take the Jackpot identity, Alana Jobson who died, and first and current heir Sara Ehret.
Mattie Franklin was the third person to be a costumed super-heroine called Spider-Woman.
The father of Felicia Hardy (the Black Cat). He was once known as the cat burglar called "The Cat".
Former New York City Police Department officer and Peter Parker's ex-girlfriend. She was briefly transformed by the Goblin Serum, but has since been returned to normal.
Harry Osborn's fiance who absorbed a unique variation of the Goblin Serum that allows her to shapeshift into a goblin. After losing those powers, she assumed the persona of Queen Cat.
Seymour was childhood friends with Peter Parker. He was later an admirer and close friend of Flash Thompson. He was eventually murdered by Venom
The ultimate club girl of New York City.
The amoral industrialist Norman Osborn was transformed by an experimental serum into the maniacal Green Goblin, and has endured over the decades as Spider-Man's most dreaded archenemy. Osborn is known for being the killer of Gwen Stacy, the architect of the Clone Saga, and the one-time director of S.H.I.E.L.D.
The mother of Black Cat and wife of Walter Hardy.
Alana Jobson was the second person to operate as the Initiative-registered superhero Jackpot (although she was the first person portrayed as Jackpot on-panel). She was a social worker who took over the Jackpot persona from Sara Ehret, using mutant growth hormone drugs to gain powers while in costume. She died in the line of duty.
Cletus Kassady is a deranged and highly dangerous serial killer and long-time host to the Carnage symbiote.
After a One More Day, with Spider-Man out of action, a crook wears a Spidey masks and mugs helpless New Yorkers.
Anna May Watson is best friends with May Parker and a paternal aunt to Mary Jane Watson. Once the Watsons were neighbors to the Parkers in Forrest Hills.
Here's Johnnnny! Host of The Tonight Show on NBC from 1962-1992.
Owner of the Daily Grind coffee shop and former employer of Ben Reilly, the Scarlet Spider.
Terry Kwan was a Tri-Corp science researcher and Peter Parker's supervisor when he worked there.
Cousin of the late Gwen Stacy, and close friend to the Parker family.
Elizabeth Allan was a classmate of Peter Parker. She dated and later married Harry Osborn, Peter's best friend. She has a son named Normie Osborn.
Roger Hochberg was a science grad student at Empire State University and a friend of Peter Parker. He dated Mia Carrerra. He has long since graduated.
A burglar Spider-Man allowed to escape at one point, he would later kill Uncle Ben.
Lance Bannon was a former rival photographer of Peter Parker and boyfriend to Amy Powell. He was later murdered by the man known only as F.A.C.A.D.E.
Mary Parker is the mother of Peter Parker (Spider-Man). However, she and her husband, Richard Parker, were killed in a plane accident when Peter was still very young.
Richard Parker is the father of Peter Parker (Spider-Man), the husband of Mary Parker, and the younger brother of Ben Parker. Richard worked for the CIA.
A demon that took over the body of mercenary and Spider-man villain Override. He later took over the body of another man, Gray Dolman.
Mary Jane Watson is an actress and a major love interest of Peter Parker aka Spider-Man. They have had a long and dramatic on-and-off-again relationship. She's one of the few people who know who he is and still supports him as a close friend and confidante.
Frederick Foswell was a reporter for the Daily Bugle and was also known as the mobster, Big Man. He later died after he bravely sacrificed his life for J. Jonah Jameson. His daughter later took up his Big Man identity.
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