Spider-Man vs an Army of Giant Lizards...
...Sort of. So the last issue The Lizard in Dr Connor's body turned the science team of Horizon Labs into giant lizards. The aftermath of this is interesting, and that's all I'll say.
The Lizard gets a new look, similar to the one from the movie. The arc comes to a satisfying end, and sets up big things for the next one.
I don't know if this series is getting a new writer in January when the series gets renumbered, but I hope not. Dan Slott has really turned this series around, and his plans for the future issues of this year are going to be big.