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Spidey has barely recovered from the Kingpin's assault, when another villain from his past re-emerges- the master of illusions, MYSTERIO!
It seems the caretaker of the Nursing home has been the old foe eking out a life bilking old folks out of their estates. After hearing of the supposed treasure the Burglar has been trying to get, Mysterio's curiousity piqued him enough to come out of retirement.
He tussles with Spider-Man and defeats him with a blow to the back of the head. He chains Spidey to a swimming pool rapidly filling with water, and leaves to hunt for the supposed treasure.