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Synapse has the ability to disrupt a persons brain and "rewire" it to his liking.  This does not, however, appear to work on the strong willed or on a person who's mind has already been altered.   When he tried to rewire DD's mind in the "Flying Blind" arc occurring thru issues #376-379,"Laurent Levasseur, agent of S.H.E.I.L.D." smiled and thanked him. 

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