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In the year 2099, Miguel O'Hara, the head of the genetics department for the Alchemax Corporation becomes the legendary hero know as Spider-Man.
Dean at Empire State University.
A chemistry and physics tutor who offers her help to Otto Octavius/Peter Parker.
Otto Octavius' former classmate and his professor while he was in possession of Peter Parker's body.
Tiberius Stone was a scientist, owner of his own multinational corporation (Viastone) and who then later worked for the Kingpin. He started working for Horizon Labs as a double-agent.
Sajani worked in Horizon Labs and currently, in Parker Industries. She is the creator of the Reverbium.
A co-worker of Peter Parker's at Horizon Labs.
Yuri Watanabe is a NYPD Captain who rose through the ranks alongside Jean DeWolff, and is an ally of Spider-Man. She is also the current Wraith.
Bella is a co-worker of Peter Parker at Horizon Labs.
Uatu is a pre-teen genius who works in Horizon Labs.
The father of the former editor of The Daily Bugle, J. Jonah Jameson, and currently married to Peter Parker's Aunt May.
Harry Osborn's fiance who absorbed a unique variation of the Goblin Serum that allows her to shapeshift into a goblin. After losing those powers, she assumed the persona of Queen Cat.
Former New York City Police Department officer and Peter Parker's ex-girlfriend. She was briefly transformed by the Goblin Serum, but has since been returned to normal.
The brother of Miguel O'Hara (aka Spider-Man 2099)
Holo-servant in the future, year 2099
The original owner of the Alchemax corporation
Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became Spider-Man.
I.C.M. built a computer in the form of a human body in order to dramatize its powers. It was the greatest mechanical brain ever built. It has been recently seen as the newest member of the Sinister Six.
Sha Shan is a Vietnamese national who has saved Flash Thompson’s life many times. After a brief stint as a Spider-Man villian called Sister Sun, she gave up crime.
Julia Carpenter is the second heroine to take up the mantle of Spider-Woman, later changing her name to Arachne. After the events of the Grim Hunt she became the new Madame Web and is currently a watcher and guardian of the Spyders.
Elizabeth Allan was a classmate of Peter Parker. She dated and later married Harry Osborn, Peter's best friend. She has a son named Normie Osborn.
Mary Jane Watson is an actress and a major love interest of Peter Parker aka Spider-Man. They have had a long and dramatic on-and-off-again relationship. She's one of the few people who know who he is and still supports him as a close friend and confidante.
Normie Osborn is the son of Harry Osborn and Liz Allan Osborn.
A former lover of Doctor Octopus and enemy of Spider-Man who uses virtual reality to become her alter-ego.
Secretary to J. Jonah Jameson.
Betty Brant started as a personal secretary at the Daily Bugle and later became a top reporter. Betty is also one of the many love interests of Peter Parker and ex-girlfriend of Flash Thompson
Editor-in-Chief of the Daily Bugle, and perhaps the best friend to J. Jonah Jameson.
Peter Parker's aunt-by-marriage and one of the most important people in his life.
J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
Doctor Octopus is a supervillain originating from Marvel Comics. A former nuclear physicist and atomic researcher, Otto Octavius' life changed forever when one of his experiments went horribly wrong involving his four mechanical appendages used to assist him in his experiments. From then on, Octavius soon after his initial encounter has become one of the most dangerous supervillains in the Marvel Universe.
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