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Richard Parker is the father of Peter Parker (Spider-Man), the husband of Mary Parker, and the younger brother of Ben Parker. Richard worked for the CIA.
Alistair Smythe is the son of Spencer Smythe: a mad scientist responsible for the creation of Spider-Slayers; robots designed to hunt and kill Spider-man. After his death Alistair carried on his work.
Eddie Brock bonded with the dark alien symbiote after it was discarded by Spider-Man, becoming the first Venom. Later, Brock became Anti-Venom, but the symbiote was lost during the events of Spider-Island. Brock has also been forcibly bonded to the Toxin Symbiote by the Crime-Master, but has reluctantly given it up to stop Carnage. Recently he has re-bonded with Venom.
Roderick Kingsley became a worthy heir of the Goblin legacy, creating his own identity, of the Hobgoblin, rather than being just another Green Goblin clone.
Second half of the criminal duo Styx and Stone who clashed with Spider-Man.
Brian "Tiny" McKeever was a friend of Flash Thompson's and part of the popular crowd. Currently, he's the head of security for Empire State University.
Ned Leeds was a Daily Bugle reporter whom Roderick Kingsley brainwashed into becoming the Hobgoblin until his eventual demise.
Frederick Foswell was a reporter for the Daily Bugle and was also known as the mobster, Big Man. He later died after he bravely sacrificed his life for J. Jonah Jameson. His daughter later took up his Big Man identity.
Mary Jane Watson is an actress and a major love interest of Peter Parker aka Spider-Man. They have had a long and dramatic on-and-off-again relationship. She's one of the few people who know who he is and still supports him as a close friend and confidante.
Son of Wilson and Vanessa Fisk. Took up the identity of The Rose to become a rival to his father, and later became Blood Rose to act as a vigilante who openly fought against his father.
A nuclear physicist and Communist agent in the People's Republic of China, Chen Lu is a Chinese superhero who's nationality has seen him come into conflict with American heroes. He has the ability to control and emit deadly forms of radiation.
Mary Parker is the mother of Peter Parker (Spider-Man). However, she and her husband, Richard Parker, were killed in a plane accident when Peter was still very young.
Elizabeth Allan was a classmate of Peter Parker. She dated and later married Harry Osborn, Peter's best friend. She has a son named Normie Osborn.
Styx is a killer for hire and half of the criminal duo Styx & Stone. Styx's touch drains the life from any living thing he touches.
Part the "popular crowd" along with Flash Thompson, Brian "Tiny" McKeever, Seymour O'Reilly, and Sally Avril who were often picking on Peter Parker.
A former mad, obsessive stalker of Mary Jane Watson.
Spider-Man's enemy who is unable to feel pain.
Anna May Watson is best friends with May Parker and a paternal aunt to Mary Jane Watson. Once the Watsons were neighbors to the Parkers in Forrest Hills.
Bromwell is the family doctor for the Parker family.
Peter Parker's aunt-by-marriage and one of the most important people in his life.
Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became Spider-Man.
After being shot by mobsters, Jennifer Walter received a life-saving blood transfusion from her cousin Bruce Banner, aka The Hulk. Due to Banner's irradiated blood, Jennifer gained the ability to transform into the Sensational She-Hulk. She is a recurring member of the Avengers.
The very mention of his name makes lesser men tremble! The brilliant scientist whose iron mask conceals his scarred (but once handsome) face! Master of science and sorcery, Victor Von Doom is the monarch of Latveria, attempting the betterment of humanity through world conquest! Unequaled and unrivaled in every manner, Doctor Doom has had many conflicts with both earthly and cosmic super-beings, but he will always be known as the eternal nemesis of Reed Richards and his accursed Fantastic Four!
Gwen Stacy was the first true love of Peter Parker. She's best known for her tragic death by being thrown off from the Brooklyn Bridge by the Green Goblin. The Earth-65 version is Spider-Gwen who is a major player in the Spider family.
The Kingpin is a supervillain originating from Marvel Comics. The self-proclaimed kingpin of crime, Wilson Fisk is one of the most prominent figures of organized crime in the United States. He is the king of mobsters, controlling organized crime on the East Coast with an iron fist. Kingpin is a major enemy of superheroes Spider-Man and Daredevil.
Doctor Octopus is a supervillain originating from Marvel Comics. A former nuclear physicist and atomic researcher, Otto Octavius' life changed forever when one of his experiments went horribly wrong involving his four mechanical appendages used to assist him in his experiments. From then on, Octavius soon after his initial encounter has become one of the most dangerous supervillains in the Marvel Universe.
The Venom symbiote originally bonded with Peter Parker, AKA Spider-Man, during his adventure in the first Secret Wars on the Beyonder's planet called Battleworld. Initially, he thought the symbiote was just an attire. However, upon his discovery, he rejected it because he realized that it was sentient. Since then, the symbiote has bonded with several other hosts, including Eddie Brock, Angelo Fortunato, Flash Thompson, Ann Weying, and even Carol Danvers. Currently, its host is Eddie Brock.
J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
Flash frequently bullied Peter Parker but was actually Spider-Man's greatest fan. In time, Flash befriended Peter, became a decorated war hero, and eventually joined the Marvel superheroes as a symbiote host, first with Venom and then with Anti-Venom.
During World War II, Steve Rogers volunteered to receive the experimental Super-Soldier Serum. Enhanced to the pinnacle of human physical potential and armed with an unbreakable shield, he became Captain America. After a failed mission left him encased in ice for decades, he was found and revived by the Avengers, later joining their ranks and eventually becoming the team's leader.
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