If you haven't read the series and you don't want some minor and some major spoilers then read no further. You've been warned!
I'm talking from issue one forward. If you haven't read it then you're really in for a treat and if you have read and you haven't reread it in a while then do it! I myself have probably reread USM more than any other comic that I own. It's just that good! Bendis really nails what makes Peter Parker great. I mean there are times where he may only be in costume for a few panels in the entire issue and you don't even notice because the dialogue is just amazing! This is where Bendis shines. I know a lot of people had a big problem with his run on the Avengers (I was kind of one of them) but this is probably the best work Bendis has ever done, I also think that his work on USM is one of the main reasons why they gave him so much power in the 616 to do as he pleases and I'll be honest his 616 work is no where near the quality of writing that he brings to the table in USM. I think the biggest reason why people should read this series now is because SPOILERS Peter Parker dies and knowing that from the first issue on, it just adds a completely different tone to the series. I discussed this once with a friend and he really summed it up perfectly. "Knowing that Peter is going to die makes the entire book feel like the old cop in a movie saying that he's going to retire next week." There are so many times throughout the series where people like Nick Fury come out and tell Peter just how great he's going to be when he gets older or all of the times he or MJ talk about their futures together. Just little things like that make me believe that Bendis had planned Peter's death from the beginning. I'll be honest I could probably keep going on about this book for a long time and with my poor grammar and punctuation it would be like torture for the few people who will may read this so I'll just leave you with what I feel is one of the best villain speeches ever and one of my all time favorite moments from the book.
NOW GO READ IT!!!