Look it's not going to be an arc where he just kills people for nothing this one is gonna be like wolverine vs the marvel universe

look i think it would be good and show how unlimited spidey can be and see if he will survive this is an idea

look one day the kree or skrull or any alien race comes and brain washes the avengers and fantastic four and then they go and collect other heros and lets say spidey is immune to it since the brain washing mechanisme is only radiation and his spider sense can help resist it so he trys to get other heros to help him and ones who are immune to it as well like deadpool or wolverine will it work

@sammystorm75: Maybe

Why don't they have Peter Parker do a Quantum Leap by jumping from different alternate universe to help solve their problems. For example, it might be interesting to see him sent to Earth-8545 to assist Mary Jane(Spider-Woman) followed by going to AoA(Earth-295) to team-up with Gwen Stacy.

http://marvel.wikia.com/Mary_Jane_Watson_%28Earth-8545%29

Wouldn't be great to see Mary Jane(Earth-8545) and Gwen Stacy(Earth-295) working together with Spider-Man(Earth-616)?

Why don't they have Spider-man vs Teenage mutant ninja turtles?

@JimTheSurfer said:

Why don't they have Spider-man vs Teenage mutant ninja turtles?

That would be awesome. Since Disney OWNS Marvel, it's unlikely to see that crossover. I even asked about the idea of Spider-Man and Captain Marvel vs X-O Manowar, and they said unlikely.

It would be nice. But it would turn out like that parody with Deadpool.

World War Arachnids . They need to send him away for a longer period of time.