I have this idea for a what if - what if the burgler who killed uncle ben killed aunt may too. At sixteen years of age what sort of impact would that have on Peter Parker? Uncle Ben's death taught him that with great power comes great responsibility but if he lost aunt may too .... would he have interpreted it in another way? Perhaps his approach to fighting super villains would be a little different and maybe he would be more willing to kill repeat offenders like norman and kingpin? So instead of becoming spider-man, he becomes something closer to deadpool. 
What do you think?

uncle ben and aunt may's values that was instilled into Peter Parker would still hold up i think. if aunt may was also killed i think Peter would be even more aware of the value of life. i just don't ever see Peter becoming a killer. but who knows.

interesting forum by the way

I think it would be nice if got adopted by Norman Osborn, at first its all fun and games for Harry to have and a brother, but then Norman begins to take Peter under his wing seeing how they share the common interest for science. Fast forward a bit and Peter and Norman are very close, so close that Pete reveals to Norman his Spider powers and how the accident accrued and how he is worried that it may further mutate him, so Norman runs test on Peter to prove that he is no longer mutating, while secretly running test to re-enact Pete's process for his own means. Harry who overheard Peters confession to Norman plots on what he should do with this information, he could blackmail Peter into running away so he can have his father all to himself again, or use the knowledge to gain power of his own.........................................writers block lol

This a very good idea. Marvel should've done this already.

Yeah it would.

He could go with the X-Men.