Character » Spider-Man appears in 17242 issues.
This donut-headed fiend is the enemy of Powdered Toast Man. He has plenty of electronic devices at his disposal.
A skill molecular biologist working for Hydra
Doctor Lemuel Dorcas was a marine biologist, genetic engineer, inventor and would-be conqueror.
Fascinated by superhuman powers, the mad genius known as Doctor Malus will go to any lengths to satisfy his curiosity. He has personally created many superhumans, and is responsible for much of the Power Brokers' work in giving people superpowers.
The blue skinned Kree genetic scientist and spy to the home-world of Kree-Lar found Captain Mar-Vell's genetic attributes as a viable mate. Gaining similar powers to Ms.Marvel she joined the Kree Starforce and later would be a major player in the end of the aging Kree Empire.
A common enemy of Hank Pym.
Noah Boddy is a brilliant scientist who has somehow found a way to make himself invisible.
Member of the Skrull police tam that came to Earth to capture De'Lila and return her to their home world.
The Original Count Dracula from Bram Stoker's famous novel. His character has been explored in many comics, including those released by Marvel, DC and many other publishers.
Carlton T. Hackmutter was once an ill-tempered janitor at Spider-Girl's high school who thought all the kids were punks. When his blood covered a ancient medallion in his dragon collection, he became a dragon himself.
Peter Parker is the Amazing Spider-Man. As a teenager, Peter was bitten by a radioactive spider and gifted with its powers. After the murder of his Uncle Ben, he vowed to use his powers for good.
One of Nefaria's Ani-Men, originally just a costumed crook who was later mutated into a permanent form. Can mesmerize others into immobility with the hum from her wings.
Spider-Man helps Vengeance fight Dread after he escapes from a police station with the help of his friend, Rak.
Bram Velsing was once a Latverian scientist, until he was disfigured by Doctor Doom. Declaring revenge, he became the Dreadknight.
A backwards-aging life energy predator who battled both Spider-man and Iron Fist.
A thin razor of a man, Ebony Maw wins his battles not through the application of force, but through the webs of lies and manipulation he weaves. Though his methods are unconventional, his knack for results has earned him the respect of Thanos. He is one of the five generals of the Cull Obsidian.
Eddie Brock bonded with the dark alien symbiote after it was discarded by Spider-Man, becoming the first Venom. Later, Brock became Anti-Venom, but the symbiote was lost during the events of Spider-Island. Brock has also been forcibly bonded to the Toxin Symbiote by the Crime-Master, but has reluctantly given it up to stop Carnage. Recently he has re-bonded with Venom.
Eddie Costanza is a small time criminal. He was killed by an alternate reality Spider-Man.
Calling himself the Supreme Hydra. Edgar attempted to take over control of Hydra while Baron Von Strucker was in suspended animation.
Edifice Rex is the Cosmically Anal-Retentive being who's motto is to Clean, Repair and Restore. Can use his Anal-Awareness to predict disasters
Edward Lavell took the mantle of the Eel from the deceased Leopold Stryke, and has upgraded his armor and technology to enhance his criminal lifestyle.
Leopold Stryke was the original super-villain known as the Eel and was the brother of the late Jordan Stryke, the original Viper.
Egghead is a loathsome scientist who quickly became a nemesis to Hank Pym.
Ego is an intelligent, living planet that is millions of years old and devours anything in its path.
When El Dorado attempted to kill El Muerto, Spider-Man came to El Muerto's aid. He fought El Dorado and was eventually able to defeat him.
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