Beast, Archangel, Rogue, Bishop and Gambit are honing their skills in the danger room, where each character gets a chance to display their unique mutant super powers. After the exercise is over and the dust settles Hank McCoy (aka, The Beast) and Warren Worthington III (aka The Archangel) meet up to talk about the good old days when they were a part of the flagship team of X-Men. Back then they both looked like normal people and could be a part of society without having to disguise and hide themselves. Warren asks McCoy if he's alright but Hank blows it off and walks away.
Back in McCoy's room, he flips through some old scrapbooks remembering before he became an X-Men when he was working at a Genetic Research company called Brand. Everything was perfect back then until a horrible accident caused Hank's mutation to change causing him to grow blue hair all over his body. Back then he was still naive of Brand's true aspirations, thinking he was contributing to the greater good of science for human and mutant kind.
An article in a newspaper has sparked all these emotions in Hank saying that Brand is about to uncover the secret of mutation, the very project McCoy was working on when he was studying there. Somehow it looks like Brand has picked up his research where he left off and he feels responsible for anything that Brand might do with the knowledge he gained from his experiments. Leaving the mansion, Rogue confronts Hank telling him he's not going anywhere alone. Knowing that he really can't explain it perfectly to her why he has to do this alone, he tells her to touch him with her bare hand, taking his thoughts and memories along with his powers, so that she'll know for sure why he has to do what needs to be done alone. She uses her powers and sees and understands what is inside Hank's soul and lets him go.
Elsewhere, in an apartment in Soho, Mary Jane Watson Parker nags Peter to get to the conference today on time because his professor is expecting a report covering what is discussed and that he doesn't really have time to go out as Spider-Man. Telling her he's just using it as cheap transportation, he kisses her and takes off out the window. Swinging over the rooftops, Spider-Man doesn't immediately see the Hobgoblin flying past him but the Hobgoblin sees him. Not really wanting to waste time fighting, the Hobgoblin tries to get by Spider-Man without being seen but he is spotted anyway and, of course, a fight breaks out. Ending it pretty quickly with a ghost slime ball to the face, sending Spider-Man plummeting to the streets below, gives the Hobgoblin the time needed to get away. Spidey does manage to get the green sludge off his face in time but not fast enough to stop the Hobgoblin or to see which way he went.
A little later Hobgoblin also runs into the Beast on the rooftops but thankfully for him, this time, the Beast doesn't see him. Down in an alleyway below Hank McCoy drops down from the roofs and takes out a long trench coat and a hat from his pack so that he can attend today's conference on mutation that Brand is giving. With his coat and hat (the perfect disguise) in place he's ready to be seen among the populace.
Peter Parker, walking into the conference notices the Beast (so much for his disguise) but can't approach him without revealing to Hank his secret identity. Inside the front doors Hank sees a colored statue of the X-Men with a caption reading "Mutation: Force Without Control?" This is all Hank needs to see to know that Brand is probably still up to it old tricks gaining support for their experimentation on mutants by spreading fear and paranoia about them.
Before going into the conference Peter sees some of Brand's results and statistics on some displays boards and comments on the fact that Brand might be mere years away from being able to give humans specific animal traits, which reminds Peter of how he got his powers. Walking into the packed house Peter notices the Beast again and wants to sit next to him hoping to be able to spark up a conversation with him about the conference. Peter would love to hear Hank's take on the presentation, but because of the crowds Peter doesn't get his chance.
Landon, the reigning CEO of Brand, makes his way to the podium at center stage and announces to the audience that Brand has now cracked the genetic code and they are ready to start splicing DNA in people, making their own mutants. Hank knows that Brand is only interested in making mutant slaves but before he can voice his opinion, the Hobgoblin bursts above the stage revealing to everyone that Landon has been doing horrible things but doesn't say what they are. The Beast, now without the coat and hat, jumps on stage and knocks the Hobgoblin away from Landon but is saved moments later by Spider-Man from an electrified net thrown at him. Hobgoblin, knowing he wouldn't be able to take on both the Beast and Spidey, throws a pumpkin bomb onto the balcony where a woman is watching the fight. With Spider-Man easily saving the woman from the blast, Hobgoblin gets frustrated and decids to leave well enough alone, blowing a hole in the wall to make his getaway. Still inside the building that is now about to collapse are the Beast and Spider-Man and still a lot of people that haven't gotten out yet.