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Once Michael Morbius was a world-renowned bio-chemist, dying of an unknown blood disease and desperately searching for a cure. He found that cure, but, in turn, it afflicted him with a curse far worse than any possible disease; the curse of the blood-sucking night-beast; the curse of the Living Vampire.
Oksana married Rhino and turned him away from a life of crime. When she was killed by the new Rhino, the original Rhino blamed Spider-Man and returned to a life of crime.
Jimmy Natale was unwillingly transformed into the new Vulture by Professor Charles Goss, who used technology similar to what created the Scorpion. This new Vulture has actual wings and fangs, and can spit acid. He blames J. Jonah Jameson for his transformation into the Vulture.
Mister Negative's newest henchman, this is a second more powerful Rhino who wield a high-tech battle axe.
Sasha was married to Kraven the Hunter.
A journalist who worked at the Daily Bugle along with Peter Parker and after Civil War in Front Line newspaper. She seems to like sarcastic humor and Peter is usually the joke.
Sha Shan is a Vietnamese national who has saved Flash Thompson’s life many times. After a brief stint as a Spider-Man villian called Sister Sun, she gave up crime.
Elizabeth Allan was a classmate of Peter Parker. She dated and later married Harry Osborn, Peter's best friend. She has a son named Normie Osborn.
Mary Jane Watson is an actress and a major love interest of Peter Parker aka Spider-Man. They have had a long and dramatic on-and-off-again relationship. She's one of the few people who know who he is and still supports him as a close friend and confidante.
Morbius' fiancée, who died and later came back as a vampire to haunt him. She has died multiple times.
Secretary to J. Jonah Jameson.
Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became Spider-Man.
One of Spider-Man's most dangerous enemies, the electric human dynamo known as Electro has constantly been a major threat for the Amazing Spider-Man.
Betty Brant started as a personal secretary at the Daily Bugle and later became a top reporter. Betty is also one of the many love interests of Peter Parker and ex-girlfriend of Flash Thompson
Harry Osborn is the best friend of Peter Parker, the Amazing Spider-Man. His father is Norman Osborn, a global industrialist and billionaire.
A career criminal, the man known as Rhino has incredible strength and durability. A long-time enemy of Spider-Man and the Incredible Hulk, Rhino isn't particularly malicious, and has tried on various occasions to leave behind his life of crime, but always seems to slide back into old habits.
Flash frequently bullied Peter Parker but was actually Spider-Man's greatest fan. In time, Flash befriended Peter, became a decorated war hero, and eventually joined the Marvel superheroes as a symbiote host, first with Venom and then with Anti-Venom.
During an experiment, Dr. Curtis Connors accidentally turned himself into a ferocious reptilian monster who seeks to turn humans into lizards like himself. The Lizard is one of Spider-Man’s oldest and deadliest foes while ironically, his alter ego is a close friend and former teacher of Spidey’s alter ego, Peter Parker.
J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
Gwen Stacy was the first true love of Peter Parker. She's best known for her tragic death by being thrown off from the Brooklyn Bridge by the Green Goblin. The Earth-65 version is Spider-Gwen who is a major player in the Spider family.
Former cat burglar Felicia Hardy became a crime fighter when she became romantically attracted to and involved with Spider-Man. Felicia has the ability to instill "bad luck" around others - this comes in handy when fighting crime!
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