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Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became Spider-Man.
Peter Parker's aunt-by-marriage and one of the most important people in his life.
The second and most successful clone of Spider-Man created by the Jackal. A superhero known as the Scarlet Spider, Reilly later replaced Peter Parker for a time as Spider-Man after he found out that all this time he was the original and not Peter. Ben met his ultimate demise in the fight against the Green Goblin which led to Peter becoming Spider-Man once again, after he found out that he is the real Spider-Man after all.
Kaine was the first clone of Spider-Man created by the Jackal. He was suffering from clone degeneration and became an assassin and spent years tormenting his clone brother, Ben Reilly. He has since taken up the mantle his now dead brother as the new Scarlet Spider.
Mary Jane Watson is an actress and a major love interest of Peter Parker aka Spider-Man. They have had a long and dramatic on-and-off-again relationship. She's one of the few people who know who he is and still supports him as a close friend and confidante.
The amoral industrialist Norman Osborn was transformed by an experimental serum into the maniacal Green Goblin, and has endured over the decades as Spider-Man's most dreaded archenemy. Osborn is known for being the killer of Gwen Stacy, the architect of the Clone Saga, and the one-time director of S.H.I.E.L.D.
The Jackal is an enemy of Spider-Man who played a big role in both of the Clone Sagas. He has since seemingly returned to infest Manhattan with spider-powers for his own sinister ends, organizing test subjects into a spider-powered army.
Devon is the son of Shirley Washington Lewis and worked at her coffee shop, the Daily Grind.
Owner of the Daily Grind coffee shop and former employer of Ben Reilly, the Scarlet Spider.
The daughter of Peter Parker, the original Spider-Man, May "Mayday" Parker continues her father's legacy as the Spider-Woman of Earth-982 (MC2 Universe).
Buzz was a regular customer to the Daily Grind, a place where Ben Reilly (the Scarlet Spider) used to work. (Buzz is not to be mistaken for the superhero "Buzz" from the Spider-girl comics).
The Gwen Stacy clone was created by Professor Warren. She walked into Peter's life after the death of the original Gwen Stacy as a form of psychological warfare on Warren's part.
Doctor Octopus is a supervillain originating from Marvel Comics. A former nuclear physicist and atomic researcher, Otto Octavius' life changed forever when one of his experiments went horribly wrong involving his four mechanical appendages used to assist him in his experiments. From then on, Octavius soon after his initial encounter has become one of the most dangerous supervillains in the Marvel Universe.
Harry Osborn is the best friend of Peter Parker, the Amazing Spider-Man. His father is Norman Osborn, a global industrialist and billionaire.
Peter Parker's uncle and the father figure whose death was the main inspiration for Peter becoming Spider-Man. Ben Parker taught Peter that with great power comes great responsibility.
Hired agent of Norman Osborn, Alison Mongrain is the alleged murderer of Peter and Mary Jane Parker's unborn baby May.
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