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Former New York City Police Department officer and Peter Parker's ex-girlfriend. She was briefly transformed by the Goblin Serum, but has since been returned to normal.
Harry Osborn is the best friend of Peter Parker, the Amazing Spider-Man. His father is Norman Osborn, a global industrialist and billionaire.
Betty Brant started as a personal secretary at the Daily Bugle and later became a top reporter. Betty is also one of the many love interests of Peter Parker and ex-girlfriend of Flash Thompson
Harry Osborn's fiance who absorbed a unique variation of the Goblin Serum that allows her to shapeshift into a goblin. After losing those powers, she assumed the persona of Queen Cat.
Rumor monger and scandal sheet printer, Dexter Bennett became the latest owner of the Daily Bugle after a hostile buyout of long-time owner J. Jonah Jameson.
Editor-in-Chief of the Daily Bugle, and perhaps the best friend to J. Jonah Jameson.
Peter Parker's aunt-by-marriage and one of the most important people in his life.
J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
Spider-Man villain with Hydrokinesis (the ability to control water), often part of teams with vendettas against the wall-crawler. Embodies the literal opposite of Spidey's other foe, Sandman.
Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became Spider-Man.
A genius chemist who invented a potent multi-polymer adhesive and immediately decided to use his invention to commit crimes. First assuming the identity of Paste-Pot Pete, he changed it to the more intimidating name of the Trapster.
Jackpot is a new registered hero with The Initiative who fights in New York City. There have been two people to take the Jackpot identity, Alana Jobson who died, and first and current heir Sara Ehret.
Mary Jane Watson is an actress and a major love interest of Peter Parker aka Spider-Man. They have had a long and dramatic on-and-off-again relationship. She's one of the few people who know who he is and still supports him as a close friend and confidante.
A police officer in New York. Doesn't have faith that Spider-Man is a good guy.
A long time member of the Enforcers and one of the oldest foes of Spider-Man. Ox, as his name suggests, was the powerhouse of the team. There have been two people named Ox, they were brothers.
Formerly a brilliant scientist, Jonathon Ohnn gained the ability to create teleportation portals when his research went wrong. Turning to a life of crime and adopting the moniker of 'The Spot', Ohnn has since become a semi-frequent adversary to Spider-Man and is oft treated as a less than serious threat despite his capabilities.
A man who would later take the name of Martin Li, was given an experimental drug which eventually allowed him control of some type of black electrical energy resembling a photographic negative.
Junkie who hangs out at the homeless shelter where May Parker volunteers.
D.A. turned-Mayoral Candidate Bill Hollister. Father of Harry Osborn's girlfriend, Lily.
A powerhouse thug that has tangled with Spider-Man and Daredevil.
Former call girl and member of many organizations, most notably the Serpent Society and B.A.D. Girls Inc.
Puff Adder is a member of the Serpent Society. He has the ability to expand his size and musculature. He also can spew an acidic cloud from his mouth at a very close range.
Rattler is a member of the Serpent Society with the ability to create vibrations with his bionic tail.
Poundcakes is a female wrestler with the ability to create shockwaves and tremors with her seismic boots.
Coachwhip is a serpent-themed villain most often affiliated with either Viper or the Serpent Society.
Blue Shield is crimefighter who sought to destroy the mob from within.
Doctor Bong is a former journalist turned mad scientist with an unhealthy obession for Beverly Switzler, who he first met in a life-drawing class. He's primarily an arch-enemy of Howard the Duck.
As a child, Matt Murdock was blinded by radioactive waste while trying to save an elderly stranger about to get hit by a truck carrying the dangerous material. In turn, his other senses were heightened to superhuman sharpness and he gained a form of "radar sense". By day, he is a successful trial lawyer; but by night, he guards Hell's Kitchen as Daredevil: the Man Without Fear.
A former member of the Circus of Crime, Griffin is a gamma-irradiated member of the Gamma Corps.
Donny Callahan received augmented abilities by a criminal organization to become a super criminal called the Squid.
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