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Spidercide is a clone of Spider-Man created by the Jackal (who has created the majority of the Spider-Man clones) who made Spidercide believe he was the true Peter Parker. Spidercide's insistence that he was the true Peter Parker led him down a road of violence and villainy.
Hobgoblin of 2211 is the daughter of Spider-Man 2211.
The amoral industrialist Norman Osborn was transformed by an experimental serum into the maniacal Green Goblin, and has endured over the decades as Spider-Man's most dreaded archenemy. Osborn is known for being the killer of Gwen Stacy, the architect of the Clone Saga, and the one-time director of S.H.I.E.L.D.
Headsman was a employee of Norman Osborn. After successive failed attempts at defeating a certain wall-crawling superhero, he joined Norman Osborn's black ops Thunderbolts team.
Mister Fish, an infamous villain from Luke Cage's rogue gallery, was a man who worked for the Maggia. During a heist he was effected by the radioactive isotope that they were stealing, and instead of killing him, he was mutated into a fish humanoid.
Dr. Jamoff "Max" Borne is the Spider-Man of the year 2211. He is part of a future organization called the Time-Spinners, which seeks to prevent disruptions in the time field, and prevent any imbalance in the mainstream universe. He was killed by the Chameleon of 2211.
The evil Gamesman has a plan to hypnotize all the young people and wreak havoc upon the city. A hypnotic signal he transmitted via arcade games transformed mild & nerdy Francis Byte into the gaming hero, Video-Man.
A backwards-aging life energy predator who battled both Spider-man and Iron Fist.
Fellow student and brief girlfriend of Spider-Man
Leader of a gang called Dragon Lords in Chinatown in NYC. He is a master of the martial arts.
Maggie Lorca is a reporter for the Daily Bugle.
Super strong member of the New Enforcers.
Jason Philip Macendale, former agent of CIA, turned from the first Jack O'Lantern to the second major Hobgoblin and once the host of Demogoblin. He was rebuilt as a cyborg and remained Hobgoblin until the first Hobgoblin who was thought dead returned and killed him.
Coldheart was a government agent who blamed super-heroes and villains for the death of her son.
Dr. Connor's other reptilian experiment gone wrong who also battled Spider man
Phil Sheldon was a reporter/photographer in the Marvel Universe. He witnessed the rise of the superheroes and some of the great events and battles of the Marvel Universe.
An enemy of Spiderman.
A former member of Satan Squad and a current member of the Enforcers.
Desperate to survive, Venom's children Agony, Phage, Lasher, and Riot merged into a single entity and then joined with former Guardsmen, Scott Washington, to become the symbiote hero known as Hybrid.
A student of Mysterio who fought Spider-Man and had a rivalry with Mad Jack.
Dreadnought was created for combat by Hydra
Former secretary at the Daily Bugle who became one the Thousand's victims. He devoured her and briefly assumed her identity.
A mobster whom from time to time crossed paths with Ben Reilly, the Scarlet Spider.
Peter Parker's friend since college and Robbie Robertson's son.
Styx is a killer for hire and half of the criminal duo Styx & Stone. Styx's touch drains the life from any living thing he touches.
An intern to the Daily Bugle. At first Peter could not stand him, but they became friends later.
Inspired by the death of his brother, Elias Wirtham set out to right the wrongs that slip through the cracks. He is the vigilante heart of justice. He is Cardiac.
Melvin Gooner is a reporter for the Daily Bugle
Terrorism's greatest enemy, Solo is an adept soldier with the ability to teleport himself certain distances. As long as he lives, terror dies.
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