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Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became Spider-Man.
Gwen Stacy was the first true love of Peter Parker. She's best known for her tragic death by being thrown off from the Brooklyn Bridge by the Green Goblin. The Earth-65 version is Spider-Gwen who is a major player in the Spider family.
J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
Flash frequently bullied Peter Parker but was actually Spider-Man's greatest fan. In time, Flash befriended Peter, became a decorated war hero, and eventually joined the Marvel superheroes as a symbiote host, first with Venom and then with Anti-Venom.
Peter Parker's aunt-by-marriage and one of the most important people in his life.
Editor-in-Chief of the Daily Bugle, and perhaps the best friend to J. Jonah Jameson.
Harry Osborn is the best friend of Peter Parker, the Amazing Spider-Man. His father is Norman Osborn, a global industrialist and billionaire.
Secretary to J. Jonah Jameson.
Mary Jane Watson is an actress and a major love interest of Peter Parker aka Spider-Man. They have had a long and dramatic on-and-off-again relationship. She's one of the few people who know who he is and still supports him as a close friend and confidante.
Silvio Manfredi has always been some kind of villain. His body is almost completly made up of cybernetic parts and he is almost like a human robot.
Elizabeth Allan was a classmate of Peter Parker. She dated and later married Harry Osborn, Peter's best friend. She has a son named Normie Osborn.
Mamie Muggins was the landlord of Peter Parker (Spider-Man) in the 1970's and early1980's
Anna May Watson is best friends with May Parker and a paternal aunt to Mary Jane Watson. Once the Watsons were neighbors to the Parkers in Forrest Hills.
Harry Osborn's former psychiatrist and the third Green Goblin
The amoral industrialist Norman Osborn was transformed by an experimental serum into the maniacal Green Goblin, and has endured over the decades as Spider-Man's most dreaded archenemy. Osborn is known for being the killer of Gwen Stacy, the architect of the Clone Saga, and the one-time director of S.H.I.E.L.D.
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