Origin

On Earth-928 in the year 2099, Miguel O'Hara worked as the head of the genetics department for the Alchemax Corporation. He was working on genetic coding and splicing. He toyed with the idea of recreating the powers of the original Spider-Man from years ago.

Miguel's boss, Tyler Stone, secretly got him addicted to the drug Rapture. This highly addictive drug couldn't be worked out of the body. It was Stone's way of controlling his employees by offering them the expensive drug in return for their loyalty.

Miguel decided to try to genetically cure himself by rewriting his genetic code from a sample he had taken previously. He was being watched by a competitive co-worker who attempted to sabotage his experiment by adding a random code into the process.

The results cured Miguel but also gave him spider-like powers. Grabbing a costume from a Day of the Dead celebration, Miguel began fighting crime and the evil corporate Alchemax as Spider-Man.

Powers

Showing finger-talons and venom fangs.

Spider-Man 2099 has powers similar to the modern day Spider-Man. He has superhuman strength, agility, durability, speed, reflexes, hearing and eyesight. His Healing abilities are also heightened. But, he does not have a healing factor. He has spinnerets in his forearms able to shoot organic webbing out of his wrist.

Spider-man shooting his webs out of his wrist.

Using his Fangs against the Sub-mariner of 2099.

Miguel also has genius-level intelligence and is especially gifted in genetics.

He doesn't have any extra sense like Spider-Man's danger sense, but makes up for it with all his enhanced senses, and doesn't web-swing as much as Spider-Man either, but is able to travel as fast as the Original Spider-man is. Instead he uses a web cape for gliding. His "web cape" was given to him by a "Thorite". One of Thor worshippers. This Thorite believed that Spider-man is the Harbinger of Thor, and gave it to him, because: "The Spider-man must be masked". Is what Thorite said. His costume is composed of Unstable Molecule Fabric (UMF). So, he can go around the city without his Talons cutting up his own costume.

Alternate Realities

Exiles (Earth-6375)

During a battle when the interdimensional team known as the Exiles visited Earth-928, Miguel's identity was exposed to the entire world when he was unmasked by Hulk 2099, who was possessed by Proteus. Rather than being hunted by Alchemax, Miguel decided to join the Exiles in trying to fix timelines that went wrong. When the all of the members were scattered throughout different realities, Miguel settle on an alternate earth with a new girlfriend.

Larval Universe 2099 (What the--?!)

In this reality, Miguel O'Hara is turned into Piguel O'Hara, a laboratory janitor who got bathed in spider venom and was granted spider-like powers. He then become the hero, Spider-Ham 15.88 .