When the Celestials experimented with the Skrulls they created two sub-species of them; Dire Wraiths (the equal of Deviants for Skrulls) there perfect genetic counterpats were the Prime-Skrulls (the equal of an Eternal for Skrulls). However the Prime-Skrulls evolved way to fast and the Celestial judgment as a problem and destroy them all. Some how the young Prime-Skrull who’s name is never reveal survived. In 1947 he was discover by other Skrulls who hunt after him, having no other solution he fled to Earth were and was pursuit by a regular Skrull. The both of them crash in planet Earth and were study in Wright-Patterson Air Force Base. There Dr. Caitlin Maddox manage to obtained an enzyme that could speed up human evolution, in the same way the Prime-Skrulls had hyper-evolve. This enzyme was derive from the Prime-Skrull’s adrenaline and also made people immune to the Black Legacy.