What You Need To Know

A secondary mutation is when a mutant develops a new mutation/new power. This mutation could do various thing, from giving a new power to returning an old power or building on an old mutation.

Examples

Emma Frost - When Genosha was attacked by Cassandra Nova's Sentinels, and they killed most of the mutants living there, Emma Frost's second mutation saved her life. Her new power is the ability to turn her body into near-indestructable diamond, but this power blocks her telepathy.

Black Tom Cassidy - Gained the power of clorokinesis (he turned into and was able to control all plant life). He lost this power when M-Day struck.

Iceman - Iceman's secondary mutation was directly linked to his first: his body was completely turned to ice, and he wasn't able to change back and forth between human and ice form. In this form, if he was destroyed he was basically immortal because he was able to reform himself from water. He lost this power due to M-Day.

Beast - Beast has some sort of secondary mutation, that seems to keep evolving. His beast form evolves to something new.

Jean Grey - Somehow, Jean Grey's secondary mutation allowed her original power of telekinesis to return.

Angel - Angel recently developed the power to heal others with his blood, providing they're the same blood-type. Although, this mutation could have always been there, and he didn't realize it, because Icarus, a mutant with simular powers, had healing powers and they derived from his wings.

Warpath - Warpath developed the power of self-propelled flight, although for some reason it has never been stated officially that this was a second mutation. This hasn't been exhibeted in a while, but he did display some sort of ability to either jump far or fly again recently.

Polaris - After her powers were drained by her alleged half-sister, Zaladane, Polaris developed the ability of super-strength, but she generated negative emotions while doing this. Her powers were later returned and this secondary mutation disappeared.