Sareena was once one of Quan Chi's three personal assassins ordered to kill Sub-Zero before he reached Quan Chi. In Mortal Kombat Mythologies: Sub-Zero, she is "fractionally faster and a more accomplished fighter than her fellow assassins."After being spared by Sub-Zero, she assists him in defeating Quan Chi.
After expressing her desire to escape the Netherrealm with him, she is shot in the back by Shinnok. As it is later revealed in Mortal Kombat: Tournament Edition the attack destroyed her human form and that her essence was then banished as punishment for her betrayal.
After years of torture, Sareena escapes the Netherrealm in her human appearance before MK: Deadly Alliance, during which she encounters the younger Sub-Zero; the brother of the one she met before. Feeling he owed her for helping his brother, Sub-Zero grants her sanctuary with the Lin Kuei back on Earthrealm.
In MK: Armageddon Sareena follows Sub-Zero into the Netherrealm, saving him from being killed by Noob Saibot and Smoke.
After the battle, Sareena loses her human form and returns to her true demon self. She is later ambushed by Quan Chi, who returns her to human form and convinces her to join him, despite her resistance.
In MK: Armageddon Konquest, Sareena, Kia and Jataaka are ordered by Quan Chi to kill Taven. The three assassins are defeated by Taven, however Sareena was freed from Quan Chi's control.
In her Armageddon ending, Sareena defeats Blaze, causing his power to flow into her. She is left unconscious until Sub-Zero reaches the top of the pyramid and revives her. When she awakens, Sareena realizes that she had gained the ability to freeze. She then confronts Quan Chi and freezes him in a block of ice. Sareena and Sub-Zero place the sorcerer in the Lin Kuei temple, where he will remain frozen forever.