First off from my understanding of the scans from Avenegrs Academy and Daken, the last few issues of The Runaway was retconned, and Old Lace is actually okay. So I will start off with the roster.
Chase with Old Lace
Nothing really new there so lets move on.
Story arcs/ Themes to include.
1) Child trafficking- I could see this being a major story arc for The Runaways. A cosntant theme of The Runaways was saving and helping children from problems stemming from Adults, be it parents or parental figures or not. Child Trafficking is a huge problem in the coutry, it is a global black market " industry" with various gangs and criminal syndicates( maybe you can use The Hand, The Kingpin, some other crime team) involved in it. The Runaways ending up getting caught up witha ring and working to brining it down would be an excellent story in my book, especially if handled seriously and writen well, it might even bring more attention to this major problem in society.
2) Teenage drug use and Gang violence- This is another major problem in society, teenage gangs, or teenagers being pressured in to gangs by older family member and people in the community. Teenage drug use is also pretty high. If mutants start to grow up in population again, then you can even include the various " mutant power" giving/enhancing drugs in to the mix for some real super powered challenges.
3) Runaways Mission in Space and the return of Xavin- Okay I really havent thought this one fully through, but I want it to happen. D:. If Xavin is still posing as Karolina maybe she sends a message to earth needing the runaways assitance. Idk.
4) Crossover with Luke Cage- I know a recurring theme with Luke cage is his child getting kidnapped or he thought she was kidnapped, but I think it would be intresting if this scenario brought " The Runaways" and Luke Cage together. But what if The Runaways after saving her feel that with all these threats that maybe, she is not truely safe with Cage. Eventually coming to the senses that they don't have the logistics and it can be just as dangerous, but not after a fight with him of course.
5) Bring Gert back some how!- I don't know this one either, but she brought something to the team and I really wish she hadn't died. Even though I understand her sacrifice. v.v
And thosse are just some of the things I would like to see.