The issue starts with two mysterious voices talking about The Runaways. The intro provides information about each member of the team and a brief history for new readers or old ones who've forgotten.
After the intro, the team is shown eating at a fancy restaurant in New York where they await an unnamed man who was one of the voices in the intro. The man is quickly revealed to be The Kingpin. The Runaways, claiming to be the new Pride, demand protection while they are in New York. Kingpin tells them he can have them killed, but he gives them a place to stay anyway. But only if they steal something for him.
Later, in the house that the Kingpin has given them, the Runaways discuss their new situation. Victor thinks they're turning evil by dealing with Fisk, Nico disagrees, Chase is just happy to have a place to stay, and Xavin admires the man for being a leader. Xavin praises Fisk for being a man who knows who he is and doesn't have to hide it, but turns from male to female as he does so.
The group is still unsure of what they'll do when the scene changes to show an old woman, in her house, talking to a very muscular man with lots of scars and a large sword. They talk about the Runaways and the Kingpin being oblivious to some plan the big man has concocted, but nothing specific is said.
Back at the Runaway's house, Nico and Karolina talk and Nico ends up questioning her relationship with, and the sexuality of, Xavin. Karolina gets mad and flies off and the next frame skips forward a little and shows the Runaways crashing their vehicle into a building. They've decided to work for the Kingpin and steal the artifact he asked for.
Things start off bumpy enough, with the crash landing and Xavin's difficulty of getting everyone to the right building, but it only gets worse. While most of the team in the building and Chase (and Old Lace) standing guard outside, a dark figure launches a rocket at the building. Chase is saved from a fall to his death by Old Lace, and inside, Xavin and Molly create an escape route by breaking the floor. They escape with the artifact but find themselves staring up at the guns of the Punisher. Not only that, but the mysterious man with the sword is right behind him and he looks mad.