A criminal from South Africa, Rock Python joined the Serpent Society under orders from Viper. He aided Viper in her schemes, but was quickly defeated by Captain America and his ally Nomad. When abandoned by Viper, Rock Python stuck with the group, forming a close friendship with Puff Adder and Anaconda. Despite being trained with his trick eggs, which have various effects including nerve gas and steel wires, Rock Python's enemies most often use his own weaponry against him.

During Diamondback's trial, Rock Python voted innocent, apparently having some sort of attraction to her. However, he was sent alongside Puff Adder and Anaconda to her apartment to ambush Diamondback after she escaped from the Serpent Society. Captain America attacked them, but Rock Python was able to defeat him with his rock-hard skull. He dropped the star-spangled hero from the top of the building, but upon orders from Cobra, had to leave Captain America there before they could see if he had survived the fall.

After their second attempt on Diamondback's life, by crashing their Serpent Saucer into her building, Rock Python and Puff Adder were thrown from the sky by Modam. They both survived the fall, and were taken into custody after telling Captain America of the events. The pair somehow escaped prison and made it back to the Serpent Society, which had taken up in Arizona.

Most recently, Rock Python was seen alongside the Serpent Society as they attempted to exact their revenge on Diamondback. He was promptly defeated by Captain America and taken into custody.