I agree with an earlier comment, the best chance anyone has to beat Thanos is during their first meeting. This is a hard pick for me seeing as how I like both dudes about the same. Thanos has taken over the MU more time than anybody else through knowledge and not power but Despero won hands down over a group of the strongest and most powerful beings in DCU. If Thanos doesn't have a back up plan then I say he loses or if Despero underestimates Thanos he goes down. I honestly want to see a team up between the two, with Purple Man and Darkseid added on to make a truly epic crossover. The 4 of them would be unstoppable.
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