Just adapt the Gauntlet/Grim Hunt to a video game. It's close enough to the same thing.
I really think that would make a great video game. It's got a pretty good story built into it. You can have lots of villains without them feeling too shoe horned in. If you include ASM #600 as part of the Gauntlet, you could have a part where the free-roaming map turns against you, which would be pretty cool. You could also have something similar to a Web of Shadows mechanic unlocked at the end of the game and available on replays, only except for the symbiote, Spider-man attacks without holding back. He'd use more brutal attacks that would do more damage, but would be slower, opening Spider-man up for attacks (I know that's not really how not holding back Spidey works, but it's gotta be balanced or no one would want to use normal Spidey).