I honestly think Slott's run is going to be about the rise, and fall, and rise again of Peter Parker.
If we look at his initial run on Amazing, it's pretty much building up his life as Peter Parker (note: not Spider-Man). Giving him a new job, new perspective on life and death, new girlfriend, new sidekick(ish)...
And what he does is show to us that Peter, and only Peter is the man for the job, even if he isn't the most efficient, or the smartest, or the strongest, by putting Ock in Spidey's shoes, and make Ock try (keyword there is try) to surpass Peter.
So if and when Peter comes back, Slott has got stories to tell about how Peter fixes everything that goes wrong in trying to make a better Spidey.
This trilogy kinda reminds me of what Grant Morrison did with Batman.