This fits into continuity after Invasion of The Spider Slayers, Maximum Carnage & then at the end it is right before Spider-Man Unlimited #3- in that issue Ock is looking for something and we don't find out till the end that he was searching for a cure for Mary Alice and she dies. Ock just loses his drive after that in that issue and gives up fighting Spidey.
Really cool to finally see a true meeting between Norman & Otto.
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