Sam and dean would stomp. Sam and Dean are basically unstoppable. Honestly there are not many superheroes who could beat them.
Sam and Dean are only ever saved by CIS or for plot reasons. Crowley, Lucifer, Dick Roman, Castiel, Michael, Gabriel, Abaddon, The Alpha Vampire...etc...any of these guys could have easily wiped the Winchesters out of existence.
That is my mistake. I meant to say with prep they are almost unstoppable.
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