I always thought that the robot Otto got in the first issue THE LIVING BRAIN was housing Otto's original brain. It just seems to crazy to me that SSM1 opened up with Otto at Peter's grave and then the same issue gets a robot that is made to house and keep a brain alive. In that issue Max tells Otto "yo what you doing in with this living brain robot???" and Otto goes "look at this!!" and Max is just like "OH MY GOD! This could mean huge things!!!" then we haven't had any kind of mention of this since.
Just to bring up your comment about Venom. How 'amazing' would it be if Venom respawn Anti-Venom to heal Peter's mind.