Who said strength would be the deciding factor? Give the Punisher the right weapons and he could blow Sparkles to pieces. Batman has done some insane stuff in comics as well so I wouldn't count him out of this either, even if it just to set up things for Castle.
Why did you pit one of my favorite characters against these guys? Alex could beat Deadpool and Wolverine, and maybe consume Hulk if he fights smart but if Hulk gets mad enough then it really won't matter.