Here is why Spider-Man loses in my eyes. Luffy is insane. In terms of the things he does, it is almost like he is the line between real and Toon Force. Look at those punche!
Spidey might sense them coming but he isn't dodging a force like that at close range. I don't want to start a fight about PIS or CIS but Hulk, Juggernaut, Rhino and others have landed blows on the Friendly Neighborhood Spider-Man.