Enemies of Deadpool
These characters have a permanent grudge against Wade Wilson, have been killed / severely damaged by him, or first appeared in a Deadpool comic.
This list does not include characters that have had casual confrontations with Deadpool, or characters that are allied to Wade as frequently as they are fighting him (like Taskmaster, Weasel, Bullseye, etc.). Included are only the ones whose antagonism to Deadpool is an essential part of their character.