See, when I think indie, what I'm really picturing is creator-owned.
I mean, Scud is indie, right? And it was published by Image; just so with Hellboy at Dark Horse or League of Extraordinary Gentlemen at America's Best. And what about Sam & Max or Bone or the Goon? Are not these all "indie" in some respect? They fall outside of the "big two" and most of them have moved around between at least two publishers or more, so shouldn't that qualify as independent?
Take Madman, for example. Started at Tundra, then went to Dark Horse, then Oni Press and finally Image. Allred takes it where he wants to take it; popularity has little to do with whether or not you would call it "indie."