I would say no. I don't see him really pulling everyone's strings or manipulating events on a large scale. Emperor Palpatine had his finger in nearly every pie and everyone dancing to his strings who plans more or less generally succeeded.
With Thanos, so far there is no evidence that he connected to The Dark Elves, Kree-Nova War, Hydra or anything else. His plans so far have failed and his minions instead of loyally serving him have all turned on him. So I would say he is not off to a great start though he may get out of his chair and put his mind to something after the events in GOTG.