Though she still struggles with interpersonal connections, Trinity is able to connect to others on some level. She is only able to do so at all because of a microsurgery performed by Antonia Dain using adamantium tools. Like young children, she must still be taught "proper behavior." Altruism and goodness are just harder for her because they're so contrary to what she was built for and what was drilled into her for the first half of her existence thus far.
At this point she has no idea how to describe her relationship with Liberty, or even her own personal feelings. It's complicated.
Because of her natural adaptability, drugs and other such things quickly become ineffective unless continuously administered at larger doses. Because of this, she was able to resist Sluurm's neurotoxin better in a second encounter. Alternatively, Antonia worried of potential susceptibility to drugs and onset of addictive behavior. Thankfully no amount of any substance they gave her had any effect thus far.
This meant she had to go through surgery in a completely wakeful state.